Please search Google for the best place to donate: http://google.com
As for me, I am promoting the World Food Program in videos & on my site because I feel it is a good cause that helps a lot of people.
You can check out what they do for yourself: http://wfp.org
I have no association with them beyond just wanting to help.
On March 11, 2011, Japan was devastated by one of the worst earthquakes in recorded history. At the current writing, the death toll stands at over 1000 people, with many thousands more still unaccounted for. Worse than the loss of life is the loss of infrastructure; entire villages have been obliterated, and hundreds of thousands are currently unable to return to their homes. Which is to say nothing of the nuclear meltdown that may or may not occur!
Basically, Japan is in a very bad way, and it’s up to us to help them.
Japan has given those of us of a nerdly sort a lot over the years: sushi, angry dogs with curly tails, unsettling pornography, feminine dudes with huge swords, painstakingly thorough RPGs, and SO MUCH MORE. It’s only right and fitting that we repay them, so we’ve decided to put together Art for Japan. Basically, we will be holding an eBay auction of cool goodies in the upcoming weeks and donating the proceeds to Japanese earthquake relief; it’s not rocket science, but like NASA, it DOES depend on you. We need you to donate whatever you can—art, books, whatever—from your creative endeavors in order to make this a roaring success. All proceeds will go to help the Japanese people dig out from under this pile of calamities, and you’ll get the warm and fuzzy feeling that comes from doing something nice for people in a whole mess of trouble.
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So! If you’re a cartoonist, illustrator, designer, animator, crafter, fine artist, etc and would like to help, please contact email@example.com! If you can send along details of what you’ll be able to contribute and when you might be able to send it to us, that’d be wonderful. If you can’t contribute, please spread the word and keep an eye out—we’re going to try and put together a quick site if we have time (if any volunteers are willing to help us out, that’d be amazing), but updates will definitely be mentioned both here and on our Twitter accounts.